Tag Archives: stem cell transplant  match

Everything You Should Know about Stem Cell Transplant Surgery


Stem cell transplant or bone marrow transplant is an advanced medical surgery performed by expert surgeons. Not much time has passed since this critical surgical procedure was introduced in the field of medical sciences. Previously, bone marrow cancers or other specific types of cancers were not treatable. At present, most patients with bone marrow cancers get treated through stem cell transplant surgeries.


Surgeons mainly suggest stem cell transplant surgeries when the patient’s bone marrow gets destructed due to cancer or chemotherapy. In such cases, doctors replace those patients’ bone marrow with stem cells to keep them alive.


What are the different types of stem cell transplants? 


Scientists and doctors have categorized stem cell transplants into three different categories- bone marrow transplant, peripheral blood stem cell transplant, and cord blood transplants. The categorization is based on where the stem cells are getting extracted from.


Besides these categories, the surgical procedure can be categorized into two other types too. Doctors determine these two types according to the donor of the stem cells. The following two types of stem cell transplants depend on the types of donors.


Autologous stem cell transplant 


In this case, the stem cells come from the patient’s own body. Surgeons extract stem cells from a specific area of the patient’s body and replace his bone marrow with those stem cells. Hence, no external donor is necessary for this procedure.


Allogeneic stem cell transplant 


In this type of transplantation, the stem cells are collected from an external donor’s body. No matter whether the donor is the patient’s relative or not, his stem cells should match with the donor for successful transplantation.


How do stem cell transplants cure cancer patients? 


Bone marrow is the origin of blood cells in the human body. Once a patient gets diagnosed with bone marrow cancer, his bone marrow doesn’t produce blood cells in adequate amounts. As the blood production rate in the patient’s body gets interrupted, his general bodily functions get interrupted too.


In such a case, doctors try to destroy all the cancer-affected bone marrow cells through chemotherapy. The higher radiation level of high-dose chemo kills the cancer cells. However, the active stem cells get killed by the chemo at the same time.


So, external stem cells are transplanted into the patient’s body for keeping blood production intact. Once all the cancer cells get killed and external stem cells are transplanted, the fresh stem cells grow up and lead the patient to complete recovery. This is how stem cell transplants cure cancer patients.


The common side effects that a cancer patient faces after a stem cell transplant surgery 


  • Throat pain and mouth pain are the most common symptoms that most patients suffer from after a stem cell transplant surgery.


  • Apart from that, patients tend to suffer from frequent infections as they don’t have white blood cells present inside their bodies.


  • Some patients report that they suffer from severe nausea and vomiting after they undergo stem cell transplant surgery.


These are all the important and relevant factors related to stem cell transplant surgery. You should keep all these points in your mind before undergoing stem cell transplant match surgery.

 Gift of Life Marrow Registry Also Offers Following Services :

Blood Cancer Donor

Bone Marrow Donation Process

How To Do A Bone Marrow Drive

Contact US:

Gift of Life Marrow Registry
Address:  800 Yamato Rd suite 101  Boca Raton, FL
Phone: (800) 962-7769

How to Be a Stem Cell Donor?

Thousands of people in U.S., every year are diagnosed with different life-threatening diseases like lymphoma, leukemia and myeloma. For such diseases, a stem cell transplant match is the best possible treatment.

However, for the transplant, blood stem cells are required. You might be considering donating bone marrow or blood to help out someone in your family as you happen to be a match. It may also be that you want to help out someone else (who is waiting for a stem cell transplant) who you do not know personally.

When a patient is using stem cells from a matching donor, then the procedure is known as allogeneic transplant. Here it is needed to mention that often times patient can even use their own stem cell, and such a transplant is known as autologous transplant.

Start with a blood test

If you are considering being a donor but do not know how to start the procedure, then firstly you need to find out if you are a match or not. So, you need to have a blood test first. The test is done to figure out your tissue typing or HLA typing. The people conducting the test in a medical lab happen to look at the surface of your blood cell. They are going to compare your blood to the surface of the blood cells belonging to the person who will be getting the mentioned type of transplant.

On the surface of the blood cells, there is your own set of proteins. The lab will look for proteins known as histocompatibility antigens and HLA markers. The lab will look for 10 HLA markers. The result of this test shows how good of a match you are with the person who needs the transplant. You might be able to still donate stem cell to a relative if your cells are a 50% match. This type of transplant, in such a scenario, is known as haploidentical transplant. But if you are not a match, then you won’t be able to be a donor.

Peripheral blood stem cell (PBSC)

Besides collecting blood from bone marrow, embryonic stem cell donation is seen in America. However, PBSC blood stem cell donation is the most common way to collect stem cell from the blood. It happens to be a non-surgical process known as apheresis. You will get filgrastim injection (5 days prior to the donation date) in order to increase you blood stem cells. At the day of the donation, your blood is removed through a needle in one arm. It will pass through a machine that only set to collect the blood-forming cells. Through a needle in your other arm, the remaining blood will be returned to you. The process is kind of similar to normal blood donating procedure. In 1 apheresis session (lasting for 8 hours) 90% of all PBSC donations will be completed. The rest 10% (lasting for 4 and 6 hours) will be completed in 2 apheresis sessions.

Where to donate?

If you want to be a donor for someone else, then you can join a volunteer registry. Before that, you can, of course, speak with a health-care provider to know about the possible side effect and recovery. You can also contact the “National Marrow Donor Program” in order to find a donor center near you. They will ask you some questions (to check if you are healthy to donate or not), and conduct the different tests to ensure that you are eligible for donating and there is no risk of infection to the one looking to get the transplant.

Contact US:

Gift of Life Marrow Registry
Address:  800 Yamato Rd suite 101  Boca Raton, FL
Phone: (800) 962-7769